Immunological and cytogenetic properties of developing thyroid tumors in the rat.
نویسندگان
چکیده
The dependent tumors exhibited minor chromosomal changes and thyroglobulin antigenicity similar to that of normal rat thyroid. The transitional tumors exhibited moderate chromosomal alterations and practically no thyroglobulin antigenicity. The autonomous tumors exhibited severe chromosomal alteration, numerically and/or structurally, and no detectable immunogenicity related to thyroglobulin. Although progressive cytogenetical and immunological alterations were observed as the tumor "evolved" from
منابع مشابه
Concurrence of Papillary Thyroid Carcinoma and Hürthle Cell Carcinoma in an Iranian Woman with Hashimoto's Thyroiditis
The most usual form of the endocrine carcinoma is thyroid cancer (TC). In addition to papillary thyroid carcinoma (PTC), recent studies revealed incidence of RET/PTC rearrangement in other tumors, like Hürthle cell carcinoma (HCC) and even in non-carcinomatous disorders like Hashimoto's thyroiditis. Here, we present a case with concurrence of papillary thyroid carcinoma and Hürthle cell carcino...
متن کاملCan previous thyroid scan induce cytogenetic radioadaptive response in patients treated by radioiodine for hyperthyroidism?
Background: Induction of radioadaptive responses in cells pretreated with a low dose radiation before exposure to a high dose is well documented by many investigators. The aim of this study is to determine the frequency of chromosomal aberration in peripheral blood lymphocytes of patients treated by radioiodine (131I) for hyperthyroidism, with or without previous thyroid scan with 99mTc. Materi...
متن کاملThe role of radiotherapy and chemotherapy in management of thyroid tumors [Persian]
Radioiodine (1-131) is the treatment of choice in differentiated thyroid carcinoma. External radiotlierapy however, has it's own roie in these tumors. Treatment of anaplastic thyroid carcinoma 1ms not acliieved any notahle success yet, though combined - modality regimens of radiotherapy and chemotherapy have sometimes shown significant results. In this paper the rol...
متن کاملSome biochemical and cytogenetic properties of rat thyroid tumors.
the host thyroid. The tumors themselves showed extremely low incorporation, although thyroidectomy of the host significantly increased the incorporation in the tumors. However, results of incorporation experiments do not distinguish the transitional from the autonomous tumors. Tumor growth also caused iodide peroxidase activity in the host thyroid to decline. The enzyme activity in the transiti...
متن کاملThe Association of 4G/5G Polymorphism of PAI-1-675 Gene with Clinicopathologic Features of Thyroid Tumors in Iranian Azeri Turkish Patients
Background: Due to the lack of information about the role of 4G/5G polymorphism of PAI-1 Gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in Iranian Azeri Turkish patients. Methods:In this case-control study, 90 patients with thyroid tumors ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 32 3 شماره
صفحات -
تاریخ انتشار 1972